Chemotherapy before or after preoperative chemoradiotherapy and surgery for locally advanced rectal cancer: 5-year results of the CAO/ARO/AIO-12 trial - a general pairwise comparison
Our 5-year GPC confirmed the 3-year findings that chemoradiotherapy followed by consolidation chemotherapy resulted in higher rates of pathological complete remission without compromising oncological outcome, toxicity, or quality of life. The TNT sequence chemoradiotherapy/chemotherapy may be preferred for organ preservation strategies.
Authors
- Rebekka Kosmala (ORCID: https://orcid.org/0000-0002-5516-4913)
- Claus Rödel
- E Fokas
- M. Fleischmann
- M. Diefenhardt
- Ralf‐Dieter Hofheinz (ORCID: https://orcid.org/0000-0001-5972-8504)
- David Martín (ORCID: https://orcid.org/0000-0002-4279-3032)
- B. Polat
- M. Ghadimi (ORCID: https://orcid.org/0009-0005-6674-3688)
Institutions
- Goethe University Frankfurt (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Hospital Frankfurt (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104483
- Citations
- 4
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Deutsche Krebshilfe