Identification of a novel small-molecule inhibitor of the HIV-1 reverse transcriptase activity with a non-nucleoside mode of action
Our data suggest that BPPT is a novel small-molecule inhibitor of HIV-1 RTase and could serve as a promising chemical scaffold to complement or replace conventional treatments, particularly for overcoming resistance associated with the G190 mutation.
Authors
- Songmee Bae
- Jaeku Kang (ORCID: https://orcid.org/0000-0002-8660-7940)
- Kyung-Lee Yu (ORCID: https://orcid.org/0000-0002-7812-8130)
- Sunwoo Kim (ORCID: https://orcid.org/0000-0002-9799-2274)
- Jeong-Ah Kim (ORCID: https://orcid.org/0000-0002-7748-1354)
- Dong‐Eun Kim (ORCID: https://orcid.org/0000-0001-6545-8387)
- Chul Min Park (ORCID: https://orcid.org/0000-0002-9707-2216)
- Pooja Singh (ORCID: https://orcid.org/0000-0003-3734-175X)
- Cheol‐Hee Yoon (ORCID: https://orcid.org/0000-0001-7999-5554)
- Keun Woo Lee (ORCID: https://orcid.org/0000-0002-0627-1800)
- YoungHyun Shin
- Ho Seok Kwon
Institutions
- Gyeongsang National University (KR)
- Korea National Institute of Health (KR)
- Korea Disease Control and Prevention Agency (KR)
- Korea Research Institute of Chemical Technology (KR)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s12985-025-02680-3
- Citations
- 3
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Korea National Institute of Health