Rationale and design of the Renal Lifecycle trial assessing the effect of dapagliflozin on cardiorenal outcomes in severe chronic kidney disease
The Renal Lifecycle trial aims to investigate the effects of the SGLT2 inhibitor dapagliflozin compared with placebo on the incidence of kidney failure, heart failure, mortality and safety in three subgroups of patients with advanced CKD.
Authors
- Dharmenaan Palamuthusingam (ORCID: https://orcid.org/0000-0003-1505-3482)
- Nathan Brinkman (ORCID: https://orcid.org/0000-0003-0815-4592)
- G. Breda (ORCID: https://orcid.org/0009-0003-9965-5022)
- Emilie Mahieu
- Dennis A. Hesselink (ORCID: https://orcid.org/0000-0003-1871-1962)
- Brendan Smyth (ORCID: https://orcid.org/0000-0003-1838-3348)
- Rosemary Masterson (ORCID: https://orcid.org/0000-0003-0810-646X)
- Ron T. Gansevoort (ORCID: https://orcid.org/0000-0002-3223-0906)
- W Bakker (ORCID: https://orcid.org/0009-0008-7203-3959)
- Michael Walsh (ORCID: https://orcid.org/0000-0001-8163-183X)
- G. William Wong (ORCID: https://orcid.org/0000-0002-5286-6506)
- J W Rood
- Rob C.M. van Kruijsdijk
- Werner Seeger (ORCID: https://orcid.org/0000-0003-1946-0894)
- Anna Laura Herzog (ORCID: https://orcid.org/0000-0002-1767-8964)
- Hemant Kulkarni (ORCID: https://orcid.org/0000-0001-6950-3341)
- Femke Waanders
- Michel P. Hermans (ORCID: https://orcid.org/0000-0002-1647-9031)
- Henk Nijmeijer (ORCID: https://orcid.org/0000-0001-5883-6191)
- WooJe Lee
- Tom Dejagere
- Marta Soler (ORCID: https://orcid.org/0000-0001-5985-4842)
- Alexander F.L. Later
- Akin Özyilmaz
- Hiddo J.L. Heerspink (ORCID: https://orcid.org/0000-0002-3126-3730)
- Christoph Wanner (ORCID: https://orcid.org/0000-0001-9507-5301)
- Anna Buxeda Porras
- Ronald van Etten
- Eugenia Pedagogos (ORCID: https://orcid.org/0009-0003-9019-8646)
- Paul Leurs
- Joost C. van den Born (ORCID: https://orcid.org/0000-0003-2637-4046)
- Margarida Marques (ORCID: https://orcid.org/0000-0002-9636-0443)
- Marc Vervloet (ORCID: https://orcid.org/0000-0003-4607-9415)
- Stefan R. A. Konings (ORCID: https://orcid.org/0000-0002-6652-6166)
- Clare Arnott (ORCID: https://orcid.org/0000-0001-9370-9913)
- Marc H. Hemmelder (ORCID: https://orcid.org/0000-0002-9598-1213)
- Maria Isabel Troya Saborido
- Vartika Srivastava (ORCID: https://orcid.org/0000-0002-8636-3413)
- Martina Guthoff (ORCID: https://orcid.org/0000-0002-4294-980X)
- Johannes Stegbauer (ORCID: https://orcid.org/0000-0001-8994-8102)
- Beatriz Sánchez Álamo
- Wim Lemahieu (ORCID: https://orcid.org/0000-0003-4893-3240)
- Arnold H. Boonstra
- Marga Eshuis
- Muh Geot Wong (ORCID: https://orcid.org/0000-0002-7575-9877)
- Manuel Macı́a (ORCID: https://orcid.org/0000-0002-0011-7706)
- Stefan P. Berger (ORCID: https://orcid.org/0000-0003-2228-4676)
- José Luis Górriz (ORCID: https://orcid.org/0000-0002-1134-9051)
- R. Krishnasamy
- Josep M. Cruzado (ORCID: https://orcid.org/0000-0003-1388-8558)
- Angela Yee‐Moon Wang (ORCID: https://orcid.org/0000-0003-2508-7117)
- Arjan M. van Alphen
- Bernhard Banas (ORCID: https://orcid.org/0000-0003-2076-2195)
- Thomas van Bemmel
- Alferso C Abrahams
- Matthias Girndt (ORCID: https://orcid.org/0000-0003-2823-0847)
- J S Wiegersma
- Dirk Kuypers (ORCID: https://orcid.org/0000-0001-5546-9680)
- Michael Schömig
- C. E. H. Siegert
- Anita van Eck van der Sluijs (ORCID: https://orcid.org/0000-0001-9119-7985)
- J J Huitema
- Gert Meeus (ORCID: https://orcid.org/0000-0002-0649-6372)
- Martin Zeier
- Lily Jakulj (ORCID: https://orcid.org/0000-0002-8678-682X)
- Frank Stifft (ORCID: https://orcid.org/0000-0002-1962-1929)
- S. J. J. Logtenberg (ORCID: https://orcid.org/0000-0002-5695-540X)
- M. Gelens
- Klemens Budde (ORCID: https://orcid.org/0000-0002-7929-5942)
- Sandrine Gaillard (ORCID: https://orcid.org/0000-0002-8964-0236)
- Henk Boom
- Shilpanjali Jesudason (ORCID: https://orcid.org/0000-0001-9695-0761)
- Martin Busch (ORCID: https://orcid.org/0000-0002-7889-6156)
- Nilda M. García (ORCID: https://orcid.org/0000-0003-2863-6388)
- Julia Weinmann‐Menke (ORCID: https://orcid.org/0000-0001-7344-8381)
- Jacqueline T. Jonker (ORCID: https://orcid.org/0009-0008-2698-8519)
- J. Bayrak
- Georg Schlieper (ORCID: https://orcid.org/0000-0001-6050-5842)
- Dominique van Mil (ORCID: https://orcid.org/0000-0002-3477-9310)
- Angela Makris (ORCID: https://orcid.org/0000-0002-1636-3493)
- Ellen K. Hoogeveen (ORCID: https://orcid.org/0000-0002-5482-2013)
- James Holt (ORCID: https://orcid.org/0000-0001-6411-9236)
- Boon Wee Teo (ORCID: https://orcid.org/0000-0002-4911-8507)
- Mario Schiffer (ORCID: https://orcid.org/0000-0002-8414-1470)
- Asunción Sancho (ORCID: https://orcid.org/0000-0002-4170-9003)
- Sunil V. Badve (ORCID: https://orcid.org/0000-0003-2269-312X)
- Manon Schouten
- Sander W.M. Keet
- Aaltje Y Adema
- Willem A. Bax (ORCID: https://orcid.org/0000-0002-2177-1475)
- Peter T Luik
- Aiko P. J. de Vries (ORCID: https://orcid.org/0000-0002-9284-3595)
- Frank Strutz
- K. Sreekanth
- Karen Keung
- Mercedes Salgueira
- J Van der Heijden
- Kate Wyburn (ORCID: https://orcid.org/0000-0002-5288-7200)
- Joep van der Leeuw
- Bernd Hohenstein (ORCID: https://orcid.org/0000-0002-7306-3825)
- Gürbey Ocak (ORCID: https://orcid.org/0000-0003-4288-7685)
- Alison E. Mather (ORCID: https://orcid.org/0000-0001-6513-3515)
- Katrien François (ORCID: https://orcid.org/0000-0002-1038-4955)
- Jeroen J P Slebe
- Miriam Blanco (ORCID: https://orcid.org/0000-0003-3572-9240)
- Juan Buades (ORCID: https://orcid.org/0000-0002-5892-0980)
- Yumiao Liu
- Peter van der Meer
- Jeroen B. van der Net
- Girish Scricant Talaulikar
- Bernd Schröppel
- EF de Maar
- F Gonzales
- Yvonne De Waal
- M Munar
- W Jansen
- Mohamed Condé
- M Goiciechea
- L Siddiqi-Nadery
- Tim C van Faassen
Institutions
- Albert Schweitzer Hospital (GA)
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Singapore General Hospital (SG)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- UNSW Sydney (AU)
- Maastricht University (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Dianet (NL)
- The George Institute for Global Health (AU)
- Universitätsklinikum Würzburg (DE)
- INCLIVA Health Research Institute (ES)
- McMaster University (CA)
- KU Leuven (BE)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1093/ndt/gfaf046
- Citations
- 15
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 19.42
Funders
- Changi General Hospital