Unique expression of genes influencing transendothelial leukocyte migration in HIV-1 resistant women in the pumwani sex worker cohort
We propose that the HIV resistant women of the PSC may exhibit a unique leukocyte migratory response in dealing with pathogen infection. The potential mechanisms could contribute to the unique leukocyte migratory response: modifications to the PI3K/AKT signaling, extracellular matrix remodeling, integrin structure and function, and activation of T-cell receptors.
Authors
- Francis A. Plummer
- Binhua Liang (ORCID: https://orcid.org/0000-0002-1108-6407)
- Joshua Kimani (ORCID: https://orcid.org/0000-0003-2858-5007)
- Ma Luo (ORCID: https://orcid.org/0000-0002-9827-4071)
- Lin Li
- Harrison Yunyang Deng
- Christian Liebzeit
- Martim Songok
Institutions
- University of Nairobi (KE)
- Public Health Agency of Canada (CA)
- Kenya Medical Research Institute (KE)
- University of Manitoba (CA)
Publication Details
- Journal
- AIDS
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1097/qad.0000000000004177
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00