Correlation of Plasma Homocysteine Level in Patients with Metabolic Syndrome

Objective: To determine the correlation of homocysteine level with metabolic syndrome (MetS) among patients presented at LUMHS.Methodology: This cross-sectional prospective study was conducted at Medicine department of Liaquat University of Medical and Health Sciences, from Dec 2020 to June 2021. Patients presented with metabolic syndrome, aged 18 to 60 years and of either gender were included. A 3ml blood sample was obtained from each patient to measure the homocysteine level. All the data will be recorded in self-made proforma and analysis was done using SPSS 20.0 version.Results: Total 90 patients of metabolic syndrome were studied; with mean age was 46.62+14.82 years, mean HDL 34.93+8.14 mg/dL and mean triglyceride as 210.97+20.50 mg/dL. Mean albumin level was 25.76+8.48 mg/g and mean homocysteine level was 15.94+5.72 mcmol/L. Overall hyperhomocysteinemia was found in 72.2% patients, which was further statistically insignificant based on genders, hypertriglyceridemia and low HDL level p-values were quite insignificant (>0.05), while its was statistically significant based on microalbuminuria (p-0.001).Conclusion: Hyperhomocysteinemia was observed to be highly frequent among patients with metabolic syndrome. Microalbuminuria was positively correlated with homocysteine levels.