Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge <i>Neopetrosia</i> cf. <i>rava</i> Collected in the Bismarck Sea
Sponges of the genus <i>Neopetrosia</i> are known for the production of a large diversity of bioactive metabolites. Contignasterines A (<b>1</b>) and B (<b>2</b>) were isolated as major metabolites of the sponge <i>Neopetrosia</i> cf. <i>rava</i> collected in the Bismarck Sea along with the known and highly bioactive steroid contignasterol (<b>3</b>) possessing a similar oxidized aglycone. Contignasterines are characterized by the presence of a 2-aminoimidazole branched on the side-chains of the oxidized steroid, and <b>1</b> also contains an unusual phosphate group at C-7. The anti-inflammatory activities of these compounds were investigated and revealed that all three compounds inhibited the production of pro-inflammatory mediators.
Authors
- Augustine Mungkaje
- Juan Ortega‐Vidal (ORCID: https://orcid.org/0000-0003-3244-3781)
- Carmen Vale (ORCID: https://orcid.org/0000-0002-9842-6223)
- Jorge R. Virués-Segovia (ORCID: https://orcid.org/0000-0001-8394-0257)
- Olivier P. Thomas (ORCID: https://orcid.org/0000-0002-5708-1409)
- Rebeca Alvariño (ORCID: https://orcid.org/0000-0001-8796-1389)
- Maggie M. Reddy (ORCID: https://orcid.org/0000-0001-8243-9567)
- Luís M. Botana (ORCID: https://orcid.org/0000-0003-2153-6608)
- Nadia Pérez-Fuentes (ORCID: https://orcid.org/0000-0003-4660-2878)
- Amparo Alfonso (ORCID: https://orcid.org/0000-0003-1572-9016)
- Svenja Burth
Institutions
- University of Papua New Guinea (PG)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Universidade de Santiago de Compostela (ES)
- Universidad de Cádiz (ES)
- Instituto de Química Orgánica General (ES)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00118
- Citations
- 1
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- Walt Disney Company
- L'Oreal USA
- United Nations Educational, Scientific and Cultural Organization
- Ministerio de Ciencia, Innovación y Universidades
- Fondation Tara Océan
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives
- Universidad de Jaén
- Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia
- Université de Recherche Paris Sciences et Lettres
- Xunta de Galicia
- Fondation Veolia Environnement
- Prince Albert II of Monaco Foundation
- Région Bretagne
- Université Côte d’Azur
- Fonds Français pour l'Environnement Mondial
- HORIZON EUROPE Framework Programme
- Agencia Estatal de Investigación
- Interreg
- H2020 Marie Skłodowska-Curie Actions
- HORIZON EUROPE Food, Bioeconomy, Natural Resources, Agriculture and Environment