A new perspective: Acyl-CoA synthetase long-chain family member 4 inhibits ubiquitin-specific protease 7-induced epithelial ovarian cancer progression by inducing ferroptosis and M1 macrophage polarization
This study reveals the critical role of USP7 in the progression of EOC. ACSL4 inhibits EOC growth and anti-apoptosis by inhibiting USP7-induced antiferroptosis and anti-M1 macrophage polarization, highlighting this mechanism as a potential therapeutic target in EOC.
Authors
- Gaoyuan Liu (ORCID: https://orcid.org/0000-0002-7216-3576)
- Limin Chen (ORCID: https://orcid.org/0000-0002-7370-6499)
- Yan Qi (ORCID: https://orcid.org/0000-0002-3168-4332)
- Qianwen Li (ORCID: https://orcid.org/0000-0002-5390-5271)
- Shuimiao Zhao
- Jing Nie (ORCID: https://orcid.org/0000-0001-5080-6553)
Institutions
- Zhangjiakou Academy of Agricultural Sciences (CN)
- Affiliated Hospital of Hebei University (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2025-03-05
- DOI
- https://doi.org/10.25259/cytojournal_241_2024
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07