NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium
This study highlights NaHS@Cy5@MS@SP as a promising strategy for the controlled and targeted delivery of H<sub>2</sub>S to synoviocytes, offering potential for RA management.
Authors
- Bao Hou
- Liying Qiu (ORCID: https://orcid.org/0000-0002-3684-792X)
- Xin-Ran Bai
- Yuanyuan Wen (ORCID: https://orcid.org/0000-0003-1239-947X)
- Ye Gu (ORCID: https://orcid.org/0000-0003-1751-908X)
- Xing Hu (ORCID: https://orcid.org/0000-0001-7495-8973)
- Weiwei Cai (ORCID: https://orcid.org/0000-0001-6795-6152)
- Xuexue Zhu (ORCID: https://orcid.org/0000-0002-4735-5648)
- Hai‐Jian Sun (ORCID: https://orcid.org/0000-0002-7791-5335)
- Yuan Du (ORCID: https://orcid.org/0000-0002-3475-9213)
- Hao‐Dong Li
- Jing Wang (ORCID: https://orcid.org/0000-0001-5246-7030)
- Zhijun Han (ORCID: https://orcid.org/0009-0009-5981-554X)
- Jia‐Bao Su
- Shijie Zhang (ORCID: https://orcid.org/0000-0002-1840-6258)
- You‐Yi Zhuang
- Xingyu Cao
- Ao-Yuan Zhang
- Lin Pan (ORCID: https://orcid.org/0000-0001-7933-318X)
- An‐Jing Xu
- Qing-Bo Lu
Institutions
- Jiangnan University (CN)
- China Pharmaceutical University (CN)
- Chinese Academy of Sciences (CN)
- Soochow University (CN)
- Suzhou Institute of Nano-tech and Nano-bionics (CN)
- Wuxi Fourth People's Hospital (CN)
- Changshu No.1 People's Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s12951-025-03286-1
- Citations
- 4
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China