Cyanobacterial circadian regulation enhances bioproduction under subjective nighttime through rewiring of carbon partitioning dynamics, redox balance orchestration, and cell cycle modulation

Our analysis of circadian regulatory rewiring of carbon metabolism and redox balancing suggests two potential approaches that could be developed for improving cyanobacterial bioproduction: leveraging natural circadian rhythms for optimizing cultivation conditions and timing of pathway induction, and engineering strains that mimic circadian-driven metabolic shifts through controlled carbon flux redistribution and redox rebalancing. While these strategies remain to be tested, they could theoretically improve the efficiency of photosynthetic bioproduction by enabling better temporal separation between cell growth, carbon storage accumulation, and product synthesis phases.

Authors

Institutions

Publication Details

Journal
Microbial Cell Factories
Published
2025-03-08
DOI
https://doi.org/10.1186/s12934-025-02665-5
Citations
4
Primary Topic
Photosynthetic Processes and Mechanisms
Type
article
Field-Weighted Citation Impact
3.22

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Cyanobacterial circadian regulation enhances bioproduction under subjective nighttime through rewiring of carbon partitioning dynamics, redox balance orchestration, and cell cycle modulation

Zachary Johnson, Margaret S. Cheung, Marija Veličković, A. Gilliam et al.
4 citations
Microbial Cell Factories
Photosynthetic Processes and Mechanisms
3.22
article

Cyanobacterial circadian regulation enhances bioproduction under subjective nighttime through rewiring of carbon partitioning dynamics, redox balance orchestration, and cell cycle modulation

Zachary Johnson, Margaret S. Cheung, Marija Veličković, A. Gilliam, M. G. García-Jiménez, Pavlo Bohutskyi, Weijun Qian, Natalie Sadler, Song Feng, Xiaolu Li, Young‐Mo Kim
article en
4 citations

Abstract

Our analysis of circadian regulatory rewiring of carbon metabolism and redox balancing suggests two potential approaches that could be developed for improving cyanobacterial bioproduction: leveraging natural circadian rhythms for optimizing cultivation conditions and timing of pathway induction, and engineering strains that mimic circadian-driven metabolic shifts through controlled carbon flux redistribution and redox rebalancing. While these strategies remain to be tested, they could theoretically improve the efficiency of photosynthetic bioproduction by enabling better temporal separation between cell growth, carbon storage accumulation, and product synthesis phases.

Microbial Cell FactoriesVol. 24(1)
Pacific Northwest National Laboratory (US), University of Washington (US), Environmental Molecular Sciences Laboratory (US), Washington State University (US)
Biological and Environmental Research, Laboratory Directed Research and Development
Openalex Percentile: Top 9%
Photosynthetic Processes and Mechanisms
3.22
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Cyanobacterial circadian regulation enhances bioproduction under subjective nighttime through rewiring of carbon partitioning dynamics, redox balance orchestration, and cell cycle modulation — Zachary Johnson, Margaret S. Cheung, et al. · Microbial Cell Factories (2025) | TGRS Research Map | TGRS