The LRP1-SHP2 pathway regulates TRPV1 sensitivity in the peripheral nervous system: Insights from amyloid beta 1–42 modulation
The findings suggest a crucial role of Aβ in modulating heat pain sensitivity during maturation through TRPV1 inhibition. The study offers new insights into the regulation of pain sensitivity during the maturation process by revealing a novel intrinsic mechanism involving Aβ<sub>1-42</sub> in heat pain sensitivity and its regulation through the LRP1/SHP2 pathway in mature adults. This pathway could be a potential therapeutic target for age-related chronic pain management.
Authors
- Temugin Berta (ORCID: https://orcid.org/0000-0002-4486-8288)
- Inbo Han (ORCID: https://orcid.org/0000-0002-0834-9325)
- Eun Jin Go (ORCID: https://orcid.org/0000-0003-0891-0263)
- Sun‐Ho Lee (ORCID: https://orcid.org/0000-0003-3357-4329)
- YunJae Jung (ORCID: https://orcid.org/0000-0002-1574-696X)
- Sung-Min Hwang (ORCID: https://orcid.org/0000-0003-2639-9761)
- Jingying Pan (ORCID: https://orcid.org/0000-0003-1363-1859)
- Gehoon Chung (ORCID: https://orcid.org/0000-0002-8036-0879)
- Mahbubur Rahman (ORCID: https://orcid.org/0000-0003-0520-2683)
- Jueun Roh
- Sang Hoon Lee (ORCID: https://orcid.org/0000-0002-3619-4340)
- Yong Ho Kim (ORCID: https://orcid.org/0000-0001-8704-3553)
- Jaeik Park
- Chul-Kyu Park
Institutions
- Gachon University (KR)
- Seoul National University (KR)
- Nantong University (CN)
- Samsung Medical Center (KR)
- New Generation University College (ET)
- CHA University Bundang Medical Center (KR)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.jare.2025.03.005
- Citations
- 3
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 4.39
Funders
- Foundation for the National Institutes of Health
- National Research Foundation of Korea
- National Institutes of Health