32P Investigating the mechanistic pathways of a novel HDAC inhibitor in neuroblastoma
methylation and expression was observed.Luciferase assay identified the putative promoter region +38 to -1024 bp to TSS of HOXD10 as active.5-aza-CdR did not affect HOXD10 levels, whereas NaB treatment repressed HOXD10 levels.Functional assays related to treated cells and stable knockdown cells are being assessed.Conclusions: Our findings suggest that HOXD10 could be a crucial oncogene in oral cancer.Understanding its role and mechanism of action could provide us with better therapeutic approaches.
Authors
- Sil R
- Prathamesh Pai (ORCID: https://orcid.org/0000-0001-9989-5534)
- Kapaettu Satyamoorthy (ORCID: https://orcid.org/0000-0002-2368-5490)
- Kampa Sundara Babitha (ORCID: https://orcid.org/0000-0002-9385-9353)
- Manasa Gangadhar Shetty
Institutions
- Manipal Academy of Higher Education (IN)
- Sri Dharmasthala Manjunatheshwara College of Dental Sciences & Hospital (IN)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104190
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Department of Biotechnology, Ministry of Science and Technology, India
- The Wellcome Trust DBT India Alliance