Recent advances in organic fluorophore-based Schiff base metal complexes: Applications in biomedicine and related fields

Schiff bases are formed through the condensation of primary amines with aldehydes or ketones. Due to their simple synthesis and versatile properties, they are highly favored as ligands in coordination chemistry. They are widely applied in fields such as biology, industry, food packaging, dyes, polymers, and oxygen detectors. Schiff base ligands are crucial in forming transition metal complexes, which serve as precursors for synthesizing metal and metal chalcogenide nanoparticles. Organic Fluorophore Schiff bases containing fluorophore groups have gained attention for their enhanced photophysical properties and broad pharmacological activities. Their metal complexes are efficient in catalyzing organic oxidation reactions. The structural diversity and ability to chelate metals make these compounds highly adaptable for various applications. This review explores the preparation, physical, biological properties, and catalytic applications of Organic Fluorophore Schiff bases metal complexes for biomedical applications. • Biophysical study of anthracene-based tripodal chemosensor. • Cytotoxicity of coumarin-based Copper(II) Complexes. • Computational studies of coumarin-thiazole-based palladium (II) complexes. • Anti-microbial study of fluorescein-based Schiff base complex. • DNA binding properties of naphthalene Schiff-base chemosensor.