96P Exploiting metabolic reprogramming via targeting novel genetic variant in urocanate hydratase 1 in histidine catabolism as a potential therapeutic approach in the treatment of colorectal cancer
Colorectal cancer (CRC), is second leading causes of cancer-related deaths. Hence there is an imperative need for the identification of new therapeutic targets. This study aimed to identify genetic variants using genome-wide DNA and RNA sequencing and Pan-Cancer Studies followed by validation cohort & functional analyses.
Authors
- Gordon A. Ferns (ORCID: https://orcid.org/0000-0002-0957-8349)
- Elisa Giovannetti (ORCID: https://orcid.org/0000-0002-7565-7504)
- Amir Avan (ORCID: https://orcid.org/0000-0002-4968-0962)
- G.J. Peters
- Hawraa Ibrahim Alshekarchi
- H. Azari
Institutions
- Queensland University of Technology (AU)
- Mashhad University of Medical Sciences (IR)
- University of Surrey (GB)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104257
- Primary Topic
- Oral and gingival health research
- Type
- article
- Field-Weighted Citation Impact
- 0.00