Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis
EndoMT is a crucial early event in pathological retinal angiogenesis, with fibronectin serving as a key mediator. Targeting fibronectin may provide a novel therapeutic strategy that could synergize with anti-VEGF treatments to more effectively treat pathological angiogenesis in diabetic retinopathy (DR) and retinopathy of prematurity (ROP), particularly in cases of poor response to anti-VEGF therapy alone.
Authors
- Zhishang Meng
- Ze Wu (ORCID: https://orcid.org/0000-0002-3135-0383)
- Fang Chen (ORCID: https://orcid.org/0000-0003-2101-1991)
- Wenyi Wu (ORCID: https://orcid.org/0000-0002-4958-8760)
- Dan Liu (ORCID: https://orcid.org/0000-0002-5731-9122)
- Pu Li (ORCID: https://orcid.org/0000-0002-5981-4119)
- Jin Chen (ORCID: https://orcid.org/0000-0003-1312-4494)
- Jing Luo
- Qi Zeng
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Hunan Provincial People's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1167/iovs.66.3.10
- Citations
- 4
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.83