CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation
Our findings indicate that CDC20 safeguards the heart against DOX-induced cardiotoxicity by modulating CCDC69 degradation without compromising the antitumor efficacy of DOX.
Authors
- Ningning Zhang (ORCID: https://orcid.org/0000-0002-2586-8792)
- Yunlong Xia (ORCID: https://orcid.org/0000-0003-4791-9666)
- Yunpeng Xie (ORCID: https://orcid.org/0000-0002-0140-1055)
- Liang Wang (ORCID: https://orcid.org/0000-0002-5247-6727)
- Xumin Guan (ORCID: https://orcid.org/0000-0002-7884-0849)
- Zhenyu Feng (ORCID: https://orcid.org/0000-0003-4187-572X)
Institutions
- Dalian Medical University (CN)
- The Central Hospital of Shaoyang (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s11658-025-00708-8
- Citations
- 4
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- National Natural Science Foundation of China
- Liaoning Revitalization Talents Program