Features of toll-like receptor genes (TLR-2, TLR-3, TLR-4 and TLR-6) polymorphism in open-angle glaucoma patients
an increase in certain genotypes in the patient group relative to the control group may indirectly indicate the involvement of infectious factors in the initiation of POAG. However, despite the proven importance of the participation of their protein products in the pathogenesis of glaucoma, the relationship of TLR polymorphism requires additional research taking into account the ethnic characteristics of patients and intergenic interactions for a better understanding of the complex mechanisms of disease development. This will help carry out early diagnosis and develop the necessary therapeutic strategy.
Authors
- В. В. Черных (ORCID: https://orcid.org/0000-0002-7623-3359)
- В. И. Коненков (ORCID: https://orcid.org/0000-0001-7385-6270)
- А. В. Шевченко (ORCID: https://orcid.org/0000-0001-5898-950X)
- V. F. Prokofiev
- А. Н. Трунов (ORCID: https://orcid.org/0000-0002-7592-8984)
Institutions
- Institute of Cytology and Genetics (RU)
- Ministry of Health of the Russian Federation (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- Intersectoral Research and Technology Complex Eye Microsurgery (RU)
- Institute of Clinical and Experimental Lymphology (RU)
Publication Details
- Journal
- Vavilov Journal of Genetics and Breeding
- Published
- 2025-03-04
- DOI
- https://doi.org/10.18699/vjgb-25-15
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.71