Association of C4d with disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis: evidence for classical/lectin complement pathway activation
The specific C4d assay revealed activity in the classical/lectin complement pathway in AAV, which reflected general disease activity, but was not associated specifically with kidney involvement. C4d levels differed depending on anti-PR3/MPO-ANCA subtypes suggesting differences in complement activation and underlying pathogenetic mechanisms. The findings imply that the classical/lectin complement pathway may play a more significant role in AAV pathogenesis than previously reported and that plasma C4d levels and C4d/C4 ratio may be biomarker candidates for disease activity and treatment outcome monitoring.
Authors
- Aleksandra Antovič (ORCID: https://orcid.org/0000-0002-7421-5069)
- Leonid Padyukov (ORCID: https://orcid.org/0000-0003-2950-5670)
- Iva Gunnarsson (ORCID: https://orcid.org/0000-0002-4514-7706)
- Myriam Martin (ORCID: https://orcid.org/0000-0003-1526-8678)
- Anna Juto
- Caroline Grönwall (ORCID: https://orcid.org/0000-0002-9111-5537)
- Anna Marie Blom (ORCID: https://orcid.org/0000-0002-1348-1734)
- Albin Björk
- Annette Bruchfeld
Institutions
- Linköping University (SE)
- Karolinska University Hospital (SE)
- Lund University (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13075-025-03503-0
- Citations
- 2
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Anna-Greta Crafoords Stiftelse för Reumatologisk Forskning
- Karolinska Institutet
- Alfred Österlunds Stiftelse
- Reumatikerförbundet