Extracellular microvesicles from patients with Rheumatoid arthritis promote dendritic cell activation in vitro
These findings demonstrate that EMVs from RA patients promote DC activation <i>in vitro</i>, suggesting a potential mechanism by which RA microenvironment perpetuates inflammation through the modulation of DC function. These knowledges provide new insight in the role of EMVs in the pathogenesis of RA and their potential role as therapeutic targets.
Authors
- Cristiano Alessandri (ORCID: https://orcid.org/0000-0003-4149-5321)
- Gloria Riitano
- Elisabetta Profumo (ORCID: https://orcid.org/0000-0002-7261-8884)
- Federica Fratini (ORCID: https://orcid.org/0000-0003-0807-930X)
- Brigitta Buttari (ORCID: https://orcid.org/0000-0002-0575-4106)
- Antonella Capozzi (ORCID: https://orcid.org/0000-0001-6508-7731)
- Maurizio Sorice (ORCID: https://orcid.org/0000-0003-3534-1502)
- Serena Recalchi
- F. M. Ucci (ORCID: https://orcid.org/0000-0002-3618-2243)
- Valeria Manganelli (ORCID: https://orcid.org/0000-0001-8517-4533)
- Tina Garofalo (ORCID: https://orcid.org/0000-0003-0645-2510)
- Agostina Longo (ORCID: https://orcid.org/0000-0002-1384-4232)
- Fabrizio Conti
- Roberta Misasi
Institutions
- Istituto Superiore di Sanità (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1532114
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 5.64