HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification
HOXB4 mediated the malignant phenotypes and modulated the immune evasion via METTL7B/TKT axis. The HOXB4/METTL7B cascade and its downstream changes might be novel targets for blocking hepatocellular carcinoma progression.
Authors
- Enshuang Guo (ORCID: https://orcid.org/0000-0002-1718-8156)
- Qiuyue Hu
- Weiwei Zhu (ORCID: https://orcid.org/0000-0003-3290-0129)
- Jiankun Yang
- Lu Bai (ORCID: https://orcid.org/0000-0003-4882-6672)
- Lei Li
- Hongqiang Liu (ORCID: https://orcid.org/0000-0002-9812-6570)
- Yongjian Zhou (ORCID: https://orcid.org/0000-0002-4036-4592)
- Huifen Wang (ORCID: https://orcid.org/0000-0002-5888-9899)
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
- Yellow River Institute of Hydraulic Research (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13062-025-00620-3
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Henan Province