Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth
Peptide 5a is an efficient tumor-homing inhibitor of αvβ6- and αvβ8-integrin that after coupling to HSA, can be used as a drug to block integrin-dependent TGFβ activation in tumors and promote immunotherapeutic responses.
Authors
- Chiara Gnasso (ORCID: https://orcid.org/0000-0001-8005-5439)
- Anna Mondino (ORCID: https://orcid.org/0000-0003-0833-6927)
- Alessandro Gori (ORCID: https://orcid.org/0000-0003-1640-7238)
- Maria Chiara Bonini
- Anna Maria Gasparri (ORCID: https://orcid.org/0000-0002-1757-8699)
- Barbara Colombo (ORCID: https://orcid.org/0000-0002-4095-9633)
- Arianna Pocaterra (ORCID: https://orcid.org/0000-0002-5571-6394)
- Fulvio Magni (ORCID: https://orcid.org/0000-0002-8663-0374)
- Matteo Doglio (ORCID: https://orcid.org/0000-0003-2477-2139)
- Angelo Corti (ORCID: https://orcid.org/0000-0002-0893-6191)
- Flavio Curnis (ORCID: https://orcid.org/0000-0002-7231-9569)
- Federica Pozzi (ORCID: https://orcid.org/0000-0002-8174-2684)
- Giulia Taiè
- Andrew Smith (ORCID: https://orcid.org/0000-0001-6530-6113)
- Alessia Ugolini
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s13046-025-03352-4
- Citations
- 3
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 4.87
Funders
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro