Intrahepatic cholangiocarcinoma: correlation between histological subtype and survival

Aim . To study the pathological histological subtypes of intrahepatic cholangiocarcinoma and their impact on survival. Materials and methods . The study involved the analysis of perioperative data from 65 patients with intrahepatic cholangiocarcinoma. Among them, 32 patients (49%) were found to have the small bile duct subtype, while 33 patients (51%) were diagnosed with the large bile duct subtype. Results . The histopathological subtype of intrahepatic cholangiocarcinoma originating from large bile ducts is considered to be a significant factor affecting overall survival ( p < 0.0001) and disease-free survival ( p =0.0074). Conclusion . In clinical practice, assessing the small and large duct subtypes of intrahepatic cholangiocarcinoma is claimed to be essential for stratifying risk factors affecting disease prognosis.