Retinal Vascularization Rate Predicts Retinopathy of Prematurity and Remains Unaffected by Low-Dose Bevacizumab Treatment
UWF imaging-based ROP screening enables quantification of retinal vascularization rate, which can provide early prediction of type 1 ROP independent of BW and GA. Rate of physiological retinal vascularization does not appear to be significantly affected by ultra-low-dose anti-VEGF treatment, which has significant implications for the development of peripheral avascular retina and timing of anti-VEGF intervention to prevent disease progression in high-risk infants.
Authors
- Caroline Hartley (ORCID: https://orcid.org/0000-0002-7981-0836)
- Amandeep S. Josan (ORCID: https://orcid.org/0000-0003-1808-6546)
- Ravi Purohit (ORCID: https://orcid.org/0000-0002-9727-5275)
- Kanmin Xue (ORCID: https://orcid.org/0000-0003-0065-9131)
- Emer Chang (ORCID: https://orcid.org/0000-0001-8769-0582)
- Chetan K. Patel (ORCID: https://orcid.org/0000-0002-1409-6045)
- Sher A. Aslam (ORCID: https://orcid.org/0000-0002-0461-7652)
Institutions
- University of Oxford (GB)
- Oxford University Hospitals NHS Trust (GB)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.ajo.2025.02.040
- Citations
- 3
- Primary Topic
- Retinopathy of Prematurity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Wellcome Trust
- National Institute for Health and Care Research