11P Preclinical evaluation of an anti-transferrin receptor antibody drug conjugate targeting triple-negative breast cancer

Iron uptake plays a critical role in numerous biological processes, including cellular growth, and proliferation. Intracellular iron delivery occurs via the endocytosis of the transferrin receptor, TfR1 (CD71). As a developmentally essential protein, CD71 is ubiquitously expressed at low levels in normal cells (except erythroblasts) but is highly expressed in proliferating cancer cells. This overexpression, combined with CD71’s high internalization efficiency in tumors, makes our product INA03 an ideal candidate for an ADC program.