Cytotoxic T-cell activation profile in critically ill children with malignancies and hemophagocytic lymphohistiocytosis
The early diagnosis of hemophagocytic lymphohistiocytosis in critically ill children with malignancies (M-HLH) remains a major challenge for intensivists. Cytotoxic T-cell activation profile with the frequency of CD38 + HLA-DR+ T cells in CD8+ T cells (CD38 + HLA-DR + CD8+ T cells%) and interferon-gamma (IFN-γ) is valuable in the early identification of pediatric M-HLH. These findings will support the future implementation of T-cell activation markers in the clinical management of children with M-HLH.
Authors
- Yue Liu (ORCID: https://orcid.org/0000-0001-8042-1443)
- Shuhong Shen (ORCID: https://orcid.org/0000-0002-0001-642X)
- Yan Miu
- Sijuan Sun (ORCID: https://orcid.org/0000-0001-5514-2899)
- Jian Zhang (ORCID: https://orcid.org/0000-0003-0365-9022)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-0576-1012)
- Hong Ren (ORCID: https://orcid.org/0000-0001-9657-8832)
- Xiaohang Huang (ORCID: https://orcid.org/0000-0002-2388-238X)
Institutions
- Shanghai Jiao Tong University (CN)
- Jiading District Central Hospital (CN)
- Shanghai Children's Medical Center (CN)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1038/s41390-025-03962-w
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Natural Science Foundation of China