Reduced Prostaglandin D2 Production by Airway Fibroblasts in Nonsteroidal Anti-inflammatory Drug- Exacerbated Airway Disease

Nasal mucosa (NM) specimens were obtained from seven subjects (one woman, 342.9 yr) who had septal deviations or turbinate hypertrophy and underwent corrective surgery (control-NM).Nasal polyp (NP) specimens were collected from seven patients with AERD (four women, 48.32.6 yr) and from seven non-AERD patients (three women, 44.316.6 yr) who were treated with endoscopic surgery.The diagnosis of aspirin intolerance was confirmed by utilising an oral or lysine-aspirin nasal challenge.None of the subjects received oral or intranasal corticosteroids for at least one week before the operation or had upper airway infections in the two weeks before the operation.Control and non-AERD subjects had taken aspirin or NSAIDs without adverse reactions (asthma, rhinitis, urticaria, angioedema, or anaphylaxis).The laboratory staff involved in the ELISA study were unaware of which group the samples came from.