Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model
These findings indicate that HIV-1 infected microglia are pro-inflammatory. Although ART significantly suppressed HIV-1 levels, neuronal inflammation persisted in ART-treated HIV-1 M-BOs. Together, these findings indicate that HIV-1 infection of microglia infiltrated into BOs provides a robust in vitro model to understand the impact of HIV-1 and ART on neuroinflammation.
Authors
- Lishomwa C. Ndhlovu (ORCID: https://orcid.org/0000-0001-5427-4187)
- Susana T. Valente (ORCID: https://orcid.org/0000-0002-7854-7554)
- Stéfano M. Cirigliano (ORCID: https://orcid.org/0000-0002-2397-6263)
- Thomas A. Premeaux (ORCID: https://orcid.org/0000-0002-2103-3421)
- Stephanie Michael (ORCID: https://orcid.org/0000-0001-6438-2587)
- Howard A. Fine (ORCID: https://orcid.org/0000-0002-6169-5702)
- Courtney Friday
- Douglas F. Nixon (ORCID: https://orcid.org/0000-0002-2801-1786)
- Robert L. Furler O’Brien (ORCID: https://orcid.org/0000-0001-5706-4871)
- Sonia Mediouni
- Samuel Martínez-Meza (ORCID: https://orcid.org/0009-0006-4672-1796)
Institutions
- Scripps Research Institute (US)
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- NewYork–Presbyterian Hospital (US)
- Cornell University (US)
- New York Hospital Queens (US)
- Weill Cornell Medicine (US)
- The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s12974-025-03375-w
- Citations
- 11
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 11.40