A novel water-soluble dinuclear Pd(II) complex having 4,4′- bipyridine and diethylenetriamine ligands and its interaction with DNA and BSA
A novel dinuclear palladium(II) complex <i>i.e.,</i> [{Pd(dien)}<sub>2</sub>(µ-4,4'-bpy)]Cl<sub>4</sub>, (dien = diethylenetriamine and bpy = bipyridine), has been synthesized and characterized by means of conductivity measurement, elemental analysis, FT-IR, 1D <sup>1</sup>H NMR, 2D <sup>1</sup>H NMR and <sup>13</sup>C NMR. Binding characteristics of this complex to DNA and BSA was investigated by electronic absorption, fluorescence, electrophoresis, energy transfer, circular dichroism and cyclic voltammetry which revealed that van der Waals and hydrogen bonds are the main binding forces for the di-Pd(II) complex interaction with the mentioned biomacromolecules. The cytotoxicity assay of the di-Pd(II) complex has been performed on human acute lymphoblastic leukemia (MOLT-4) cell line. Finally, to identify DNA/BSA binding site for the metal complex, theoretical investigations were conducted utilizing molecular docking.
Authors
- Hassan Mansouri‐Torshizi (ORCID: https://orcid.org/0000-0002-8484-8767)
- Effat Dehghanian (ORCID: https://orcid.org/0000-0002-3717-0068)
- Narjes Alisufi
- Fatemeh Mohammadi (ORCID: https://orcid.org/0000-0003-1289-8922)
- Leila Dehghanian
Institutions
- Hamedan University of Medical Sciences (IR)
- Bu-Ali Sina University (IR)
- University of Applied Science and Technology (IR)
- University of Sistan and Baluchestan (IR)
Publication Details
- Journal
- Journal of Biomolecular Structure and Dynamics
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1080/07391102.2025.2475386
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00