Low-coverage whole genome sequencing of cell-free DNA to predict and track immunotherapy response in advanced non-small cell lung cancer
This study demonstrates the feasibility and potential clinical utility of lcWGS for the tumor-agnostic stratification and monitoring of advanced NSCLC under PD-(L)1 blockade based on CNV and fragmentomic profiling.
Authors
- Magdalena Görtz (ORCID: https://orcid.org/0000-0001-6195-1609)
- M. Gasser
- Petros Christopoulos (ORCID: https://orcid.org/0000-0002-7966-8980)
- Arlou Kristina Angeles (ORCID: https://orcid.org/0000-0002-1917-2932)
- Holger Sültmann (ORCID: https://orcid.org/0000-0002-5257-8600)
- Albrecht Stenzinger (ORCID: https://orcid.org/0000-0003-1001-103X)
- Anja Lisa Riediger (ORCID: https://orcid.org/0000-0002-7567-8153)
- Simon J. Ogrodnik (ORCID: https://orcid.org/0000-0002-8589-4116)
- Marc A. Schneider (ORCID: https://orcid.org/0000-0001-7534-5431)
- Michael B. Thomas (ORCID: https://orcid.org/0000-0002-5890-709X)
- Florian Janke (ORCID: https://orcid.org/0000-0002-2406-7037)
- Sabrina Gerhardt
- Astrid K. Laut
- Louise Appenheimer
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- National Center for Tumor Diseases (DE)
- German Center for Lung Research (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s13046-025-03348-0
- Citations
- 9
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 8.43