Causal relationship between Baff-R expression and normal pressure hydrocephalus: insights from Mendelian randomization analysis

Among the 22 traits, 8 Baff-R-related traits were causally related to NPH. The genetic prediction indicates that Baff-R, particularly in the area of BAFF - R on unswitched memory B cell, BAFF - R on IgD + CD38 - B cell, BAFF - R on CD24 + CD27 + B cell, BAFF - R on IgD - CD38 - B cell, BAFF - R on IgD + CD38dim B cell, BAFF - R on IgD + CD24 + B cell, BAFF - R on IgD + CD38 - naive B cell, BAFF - R on memory B cell may decrease risks on the development of NPH. These findings may help us to understand the immune mechanisms associated with NPH and help to develop future biomarkers related to the disease.