Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity
Plasma CAM levels were higher in DM patients compared to healthy controls, particularly in DM patients with ILD. Our analyses support a pathway of low PON1 lactonase activity representing poor HDL function with low protective capacity of microvessels allowing increased endothelial activation leading to DM and DM-ILD.
Authors
- T. León (ORCID: https://orcid.org/0000-0003-3595-0586)
- Christina Charles‐Schoeman (ORCID: https://orcid.org/0000-0002-1768-7019)
- Sangmee Sharon Bae (ORCID: https://orcid.org/0000-0002-7216-7219)
- Ani Shahbazian (ORCID: https://orcid.org/0009-0000-9808-4406)
- Srinivasa T. Reddy (ORCID: https://orcid.org/0000-0003-2959-9531)
- Daniela Markovic (ORCID: https://orcid.org/0009-0003-7128-280X)
- Jennifer Wang (ORCID: https://orcid.org/0000-0002-2556-9100)
- Yuna Lee (ORCID: https://orcid.org/0000-0001-5877-8286)
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s13075-025-03520-z
- Citations
- 3
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases