Therapeutic potential of isochlorogenic acid A from Taraxacum officinale in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer
ICGA-A and CRA, bioactive compounds from <i>Taraxacum officinale</i>, exhibit significant antitumor activity in TNBC by targeting the FAK/PI3K/AKT/mTOR pathway, a critical regulator of cancer progression. Their ability to modulate the tumor immune microenvironment highlights their potential as immune modulators that enhance the efficacy of immunotherapy. These findings suggest that ICGA-A and CRA could serve as promising adjuncts in TNBC treatment, offering a novel strategy to overcome challenges such as therapeutic resistance and limited treatment options. Further investigation is warranted to explore their synergistic effects with immunotherapies in improving TNBC outcomes.
Authors
- Qiang‐Qiang Jia (ORCID: https://orcid.org/0000-0003-0017-5479)
- Yuxin Lin (ORCID: https://orcid.org/0000-0001-6543-0317)
- Juan An (ORCID: https://orcid.org/0000-0002-6356-3447)
- Xueman Ma (ORCID: https://orcid.org/0000-0003-1442-6064)
- Tianyun Wang (ORCID: https://orcid.org/0000-0001-5507-7505)
- Shoude Zhang (ORCID: https://orcid.org/0000-0002-1320-2248)
- Li Wang (ORCID: https://orcid.org/0000-0002-8969-7427)
- Haiyan Wang (ORCID: https://orcid.org/0000-0001-8728-0719)
- Zhijing Wu
- Jingwei Sun (ORCID: https://orcid.org/0009-0007-7888-0625)
- Qiong Wu (ORCID: https://orcid.org/0009-0003-2589-1778)
- Zhanhai Su (ORCID: https://orcid.org/0000-0003-1292-6882)
Institutions
- Qinghai University (CN)
- Qinghai Provincial Peoples Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1529710
- Citations
- 4
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 7.00
Funders
- Qinghai Provincial Department of Science and Technology