Impact of POU3F4 mutation on cochlear development and auditory function
The POU3F4 p.E294G resulted in abnormal nuclear localization. Pou3f4 mutant disrupts cochlear development and function, impairs mitochondrial integrity, induces oxidative stress, and promotes apoptosis, leading to progressive hearing loss. The findings enhance the understanding of POU3F4-related hearing loss mechanisms and highlight the importance of early genetic screening and audiological monitoring.
Authors
- Panpan Bian (ORCID: https://orcid.org/0000-0003-4520-4106)
- Jiong Dang
- Min‐Xin Guan (ORCID: https://orcid.org/0000-0001-5067-6736)
- Yufen Guo (ORCID: https://orcid.org/0000-0002-4650-5237)
- Baicheng Xu (ORCID: https://orcid.org/0000-0002-9291-9369)
- Luhang Cai
- Wenqi Shan
- Yong Li (ORCID: https://orcid.org/0000-0001-9939-094X)
- Chi Chen (ORCID: https://orcid.org/0000-0001-9703-604X)
- Huan Tan
- Chao Chen (ORCID: https://orcid.org/0000-0002-3191-0838)
Institutions
- Lanzhou University Second Hospital (CN)
- Zhejiang University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s12964-025-02133-y
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- National Natural Science Foundation of China