Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis
Our study highlights the potential of cathepsin K inhibition for renewable cardiomyocytes and suggests exploring metabolic pathways and signaling to improve cardiac regeneration and organoid development.
Authors
- Rui Guo (ORCID: https://orcid.org/0000-0001-7417-7018)
- Shengxian Liang (ORCID: https://orcid.org/0000-0001-9796-3994)
- Li Zhong (ORCID: https://orcid.org/0000-0001-9828-3915)
- Ying Wang (ORCID: https://orcid.org/0000-0001-6642-543X)
- Xiaoyu Liu (ORCID: https://orcid.org/0000-0001-5259-7038)
- Yang Cui (ORCID: https://orcid.org/0000-0002-4668-3017)
Institutions
- Hebei University (CN)
- Western University of Health Sciences (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13287-025-04231-7
- Citations
- 2
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.19
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province