Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status
Our results highlight the translational value of the head and neck organoid models not only for patient stratification but also for mechanistic validation of therapy responsiveness of specific cancer drivers.
Authors
- Christian Issing (ORCID: https://orcid.org/0000-0002-9433-8306)
- Ria Winkelmann (ORCID: https://orcid.org/0000-0002-3772-231X)
- Andreas Loth (ORCID: https://orcid.org/0000-0001-5221-6565)
- Philipp Thoenissen (ORCID: https://orcid.org/0000-0001-6032-2835)
- Peter Johannes Wild (ORCID: https://orcid.org/0000-0002-1017-3744)
- Tahmineh Darvishi (ORCID: https://orcid.org/0009-0007-7024-275X)
- Henner F. Farin (ORCID: https://orcid.org/0000-0003-1558-5366)
- Constantin Menche (ORCID: https://orcid.org/0009-0002-1805-3605)
- Franz Rödel (ORCID: https://orcid.org/0000-0001-6057-1022)
- Maximilian Fleischmann
- Jens von der Grün (ORCID: https://orcid.org/0000-0002-9371-7814)
- Christian Brandts (ORCID: https://orcid.org/0000-0003-1732-2535)
- Mohammed H. Mosa (ORCID: https://orcid.org/0000-0002-8950-8470)
- Timo Stöver (ORCID: https://orcid.org/0000-0003-2877-000X)
- Shahram Ghanaati (ORCID: https://orcid.org/0000-0002-7897-0854)
- M. Richter
Institutions
- Goethe University Frankfurt (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital of Zurich (CH)
- Cardiovascular Center Frankfurt (DE)
- University Hospital Frankfurt (DE)
- Georg Speyer Haus (DE)
- Frankfurt Cancer Institute (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13046-025-03345-3
- Citations
- 10
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 18.48