Spermine accumulation via spermine synthase promotes tumor cell proliferation in head and neck squamous cell carcinoma
This study provides a preliminarily characterization of the metabolic profile of HNSCC and highlights spermine and its synthetic pathways as potential diagnostic and therapeutic targets. Future studies are warranted to elucidate the mechanism of action of spermine in HNSCC and explore its utility in early diagnosis and therapeutic development.
Authors
- Peng Xiao (ORCID: https://orcid.org/0000-0002-5308-8400)
- Dongxian Li (ORCID: https://orcid.org/0000-0003-0248-1584)
- Yu‐Hui Fang (ORCID: https://orcid.org/0000-0003-4319-2543)
- Yakui Mou (ORCID: https://orcid.org/0000-0003-1367-0145)
- Shijun Lv
- Xi Chen (ORCID: https://orcid.org/0000-0001-9138-1432)
- Yumei Li (ORCID: https://orcid.org/0000-0003-2344-8521)
- Fei Song (ORCID: https://orcid.org/0000-0002-3286-8782)
- Yisong Yao (ORCID: https://orcid.org/0009-0006-2952-6438)
- Xicheng Song
Institutions
- Qingdao University (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Ludong University (CN)
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s12885-025-13820-x
- Citations
- 2
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.61