Protective Effects of Bosentan via Endothelin Receptor Antagonism in Experimental Ischemia-Reperfusion Injury in the Lower Limb of Rats
Bosentan demonstrates significant protective effects against skeletal muscle IRI by reducing oxidative stress and inflammation through endothelin receptor antagonism. These findings underscore bosentan's potential as a therapeutic agent for mitigating ischemia-reperfusion injury in vascular surgeries and managing critical limb ischemia in clinical settings. Further research is warranted to explore the long-term effects of bosentan on muscle recovery and systemic health following ischemia-reperfusion injury.
Authors
- Hüseyin Demirtaş (ORCID: https://orcid.org/0000-0002-5710-1385)
- Mehmet Burak Gülcan (ORCID: https://orcid.org/0000-0003-4572-9359)
- Abdullah Özer (ORCID: https://orcid.org/0000-0003-0925-7323)
- Zeynep Yığman (ORCID: https://orcid.org/0000-0003-1985-9280)
- Mustafa Arslan (ORCID: https://orcid.org/0000-0003-4882-5063)
- Ayşegül Küçük (ORCID: https://orcid.org/0000-0001-9316-9574)
- Ali Doğan Dursun (ORCID: https://orcid.org/0000-0001-9056-0025)
- Yusuf Ünal (ORCID: https://orcid.org/0000-0001-6260-5177)
- Esra Tekin (ORCID: https://orcid.org/0000-0002-9684-3277)
Institutions
- Ankara University (TR)
- Memorial Ankara Hospital (TR)
- Erzurum Regional Training and Research Hospital (TR)
- Kutahya Saglik Bilimleri Universitesi
- Gazi University (TR)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s510885
- Citations
- 6
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 6.99