Protein epigenetic scores and overall mortality in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA)
The protein EpiScores associated with an increased mortality risk represent proteins involved in metabolic functions, immune response, and inflammation. Conversely, those associated with a lower risk represent proteins involved in neurogenesis and cellular functions. Overall, it is possible to predict protein levels from DNAm data that could have clinical relevance.
Authors
- Thaís Lopes De Oliveira (ORCID: https://orcid.org/0000-0002-0470-1459)
- Albert March (ORCID: https://orcid.org/0000-0002-8203-6482)
- Sara Hägg (ORCID: https://orcid.org/0000-0002-2452-1500)
- Jonathan K. L. Mak (ORCID: https://orcid.org/0000-0003-4454-8580)
- Nancy L. Pedersen
Institutions
- Karolinska Institutet (SE)
- University of Hong Kong (HK)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13148-025-01843-x
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Karolinska Institutet
- Vetenskapsrådet
- National Institute on Aging