An anti-CD19-exosome delivery system navigates the blood–brain barrier for targeting of central nervous system lymphoma
We present anti-CD19-Exo-MTX as a promising exosome-based drug delivery platform that enhances BBB permeability and offers specific targeting for effective CNSL treatment with reduced adverse effects.
Authors
- Lexin He
- Chuan He (ORCID: https://orcid.org/0000-0001-5249-0070)
- Linlin Qin (ORCID: https://orcid.org/0000-0002-5684-4064)
- Wenzhuo Zhuang (ORCID: https://orcid.org/0000-0002-8552-991X)
- Shushu Yuan
- Ruying Hu (ORCID: https://orcid.org/0000-0001-5928-9193)
- Bing-Zong Li (ORCID: https://orcid.org/0000-0002-2732-9354)
- Qi Li (ORCID: https://orcid.org/0000-0002-9144-148X)
- Zhiming Wang (ORCID: https://orcid.org/0009-0000-1089-7075)
- Han Zhang (ORCID: https://orcid.org/0000-0002-2154-6761)
- Yuchen Zhang (ORCID: https://orcid.org/0000-0003-3378-1520)
- Xinyun Zhang (ORCID: https://orcid.org/0009-0005-1464-9083)
- Rong Rong (ORCID: https://orcid.org/0000-0001-6261-9202)
- Meifang Zhao (ORCID: https://orcid.org/0009-0004-0970-2882)
- Menglu Chen (ORCID: https://orcid.org/0000-0002-1044-396X)
- Hongxia Cui (ORCID: https://orcid.org/0000-0002-7482-6206)
- Yali Chai
- Hao Xu (ORCID: https://orcid.org/0009-0005-6950-6020)
- Xinyuan Zhang (ORCID: https://orcid.org/0000-0003-0084-5911)
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s12951-025-03238-9
- Citations
- 26
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 20.96
Funders
- National Natural Science Foundation of China