Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis
CD36 deficiency improves HFD-induced MAFLD by inhibiting fatty acid synthesis, while accelerating MCD diet-induced MASH via promoting Cer, LPC, TG and DG accumulation to accelerate liver inflammation. The complex role of CD36 in MAFLD/MASH needs more investigation to discover the precise and effective strategy when targeting CD36.
Authors
- Xiaoxiao Yang (ORCID: https://orcid.org/0000-0002-7372-2931)
- Yajun Duan (ORCID: https://orcid.org/0000-0002-3880-9070)
- Mengmeng Zhu (ORCID: https://orcid.org/0000-0002-5161-813X)
- Yuanli Chen (ORCID: https://orcid.org/0000-0003-0813-3847)
- Wenya Zhu
- Tingting Zhang (ORCID: https://orcid.org/0000-0003-1703-4082)
- Jialing Ma (ORCID: https://orcid.org/0000-0003-3058-3983)
Institutions
- University of Science and Technology of China (CN)
- Hefei University of Technology (CN)
- Huazhong University of Science and Technology (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fphar.2025.1522177
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06