Targeted delivery of TAPI-1 via biomimetic nanoparticles ameliorates post-infarct left ventricle function and remodelling
Targeted treatment with TACE/ADAM17 inhibitor delivered via biomimetic nanoparticles exhibited pronounced advantages in improving left ventricle function, mitigating cardiac remodelling, and reducing inflammatory responses within the infarcted hearts. This study underscores the effectiveness of Neu-LNPs as a drug delivery strategy to enhance therapeutic efficacy in clinical settings.
Authors
- Qing Chen (ORCID: https://orcid.org/0000-0003-4108-7977)
- Lei Tong (ORCID: https://orcid.org/0009-0002-1412-2087)
- Shun‐Guang Wei (ORCID: https://orcid.org/0000-0003-4404-4059)
- Yang Yu (ORCID: https://orcid.org/0000-0002-8482-4626)
- Robert M. Weiß
Institutions
- University of Iowa (US)
- Veterans Health Administration (US)
- Iowa City VA Medical Center (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1093/cvr/cvaf039
- Citations
- 8
- Primary Topic
- Cardiac Structural Anomalies and Repair
- Type
- article
- Field-Weighted Citation Impact
- 16.05