Genomic characterization of a dog-mediated rabies outbreak in El Pedregal, Arequipa, Peru
Genomic insights into the El Pedregal outbreak revealed multiple introductions over a 2-year window. Eco-epidemiological conditions, including migratory worker patterns, suggest human-mediated movement drove introductions. Despite outbreak containment, El Pedregal remains at risk of dog-mediated rabies due to ongoing circulation in Arequipa, Puno, and Bolivia. Human-mediated movement of dogs presents a major risk for rabies re-emergence in Peru, jeopardizing regional dog-mediated rabies control. Additional sequence data is needed for comprehensive phylogenetic analyses.
Authors
- Elvis W. Díaz
- Kirstyn Brunker (ORCID: https://orcid.org/0000-0001-9990-6299)
- Ricardo Castillo-Neyra (ORCID: https://orcid.org/0000-0001-6629-2139)
- Natasha Palmalux (ORCID: https://orcid.org/0000-0002-4246-6082)
- Michael Z. Levy (ORCID: https://orcid.org/0000-0002-4661-3764)
- Jenna Nichols (ORCID: https://orcid.org/0000-0003-0093-7170)
- Katty Borrini-Mayorí (ORCID: https://orcid.org/0000-0003-3134-7069)
- Micaela De la Puente-León (ORCID: https://orcid.org/0000-0001-6668-5442)
- Edith Zegarra
- Ynes Monroy (ORCID: https://orcid.org/0000-0002-5311-4031)
- Katie Hampson (ORCID: https://orcid.org/0000-0001-5392-6884)
- Sandeep Kasaragod (ORCID: https://orcid.org/0000-0001-9499-3653)
- Gorky N. Baldarrago
- Renzo Salazar
Institutions
- Universidad Peruana Cayetano Heredia (PE)
- Dirección Regional de Salud del Callao (PE)
- Ministerio de Salud (NI)
- MRC University of Glasgow Centre for Virus Research (GB)
- Rice University (US)
- University of Glasgow (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1371/journal.pntd.0012396
- Citations
- 4
- Primary Topic
- Rabies epidemiology and control
- Type
- article
- Field-Weighted Citation Impact
- 4.15
Funders
- Medical Research Council
- Fogarty International Center
- Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases