Overlapping presence of β-amyloid, tau, p-tau, and α-synuclein in skin nerve fibers in Alzheimer's disease
Deposits of β-amyloid 1-42, p-SN, tau, and p-tau were detected in skin nerve fibers in both patient groups; however, qualitative assessment did not discriminate between AD and non-AD patients at this sample size. Future analyses of protein distribution and spreading in peripheral nerves may give new insights into the pathophysiology of neurodegenerative diseases, but may require quantitative detection.
Authors
- Rosa Rößling (ORCID: https://orcid.org/0000-0003-2253-1454)
- Marie-Luise Machule (ORCID: https://orcid.org/0000-0002-0969-4120)
- Maria Buthut (ORCID: https://orcid.org/0000-0002-0413-575X)
- Leon Stefanovski (ORCID: https://orcid.org/0000-0003-0197-2576)
- Emilie Buchholz (ORCID: https://orcid.org/0009-0005-9323-0714)
- Harald Prüß
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1007/s00415-025-12994-5
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Deutsche Forschungsgemeinschaft
- Charité – Universitätsmedizin Berlin