Circulating mitochondrial DNA signature in cardiometabolic patients
Patients with HF and diabetes have an altered circulating mtDNA signature characterised by higher cell-free mtDNA and lower mtDNA ratio, whereas cellular mtDNA remains unaffected. Cell-free mtDNA and mtDNA ratio are associated with impaired response to exercise, higher systemic inflammation and increased congestion. Circulating mitochondrial profile could be a new biomarker of mitochondrial status in cardiometabolic diseases.
Authors
- Stefano Masi (ORCID: https://orcid.org/0000-0002-7591-3686)
- Domenico Tricò (ORCID: https://orcid.org/0000-0002-7633-1346)
- Emiliano Duranti
- Lavinia Del Punta
- Agostino Virdis (ORCID: https://orcid.org/0000-0002-6994-0223)
- Nicola Riccardo Pugliese (ORCID: https://orcid.org/0000-0001-6466-1412)
- Federica Cappelli (ORCID: https://orcid.org/0000-0002-9720-9374)
- Nicolò De Biase (ORCID: https://orcid.org/0000-0001-9133-5217)
- Virginia Nannipieri
- Silvia Armenia
- Alessandro Mengozzi
- S. Taddei
- Rossana Remollino
Institutions
- University of Pisa (IT)
- University of Zurich (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s12933-025-02656-1
- Citations
- 18
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 24.99
Funders
- European Commission