Kratom Cardiotoxicity
Kratom is derived from Mitragyna speciosa and contains active alkaloids that bind opioid, alpha-2 adrenergic, and 5-HT2A receptors. In vitro studies show kratom can inhibit myocardial potassium channels. We present a patient who developed a reversible Brugada pattern and QT prolongation after self-treating his attention-deficit/hyperactivity disorder with kratom.
Authors
- Christine Murphy (ORCID: https://orcid.org/0000-0002-4885-3083)
- Anna R. Dulaney
- Alex J. Krotulski (ORCID: https://orcid.org/0000-0003-1775-1882)
- Allison N. Miller
- Sara E. Walton
- Aaron P Frolichstein
- Haley L Dusek
Institutions
- Carolinas Medical Center (US)
- Fredric Rieders Family Foundation (US)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jaccas.2024.103109
- Citations
- 1
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.56