Dolutegravir/Lamivudine for Maintenance of Virological Suppression in Persons With Historical Suspected or Confirmed Resistance to Lamivudine: Week 48 Results of a Single-Arm, Open-Label, Multicenter, Phase IIa Clinical Trial
After excluding lamivudine mutations in proviral DNA by population sequencing, dolutegravir/lamivudine effectively maintained virological suppression in PWH with CD4+ >200 cells/mm3 and history of lamivudine resistance. Notably, no treatment-emergent resistance was observed.
Authors
- Federico Pulido (ORCID: https://orcid.org/0000-0002-7414-8812)
- Adriana Pinto-Martínez
- Rosa de Miguel Buckley (ORCID: https://orcid.org/0000-0003-2749-818X)
- Antonio Ocampo (ORCID: https://orcid.org/0000-0002-3176-9758)
- Roser Navarro‐Soler (ORCID: https://orcid.org/0009-0001-7044-2707)
- Rocío Montejano (ORCID: https://orcid.org/0000-0002-3446-0545)
- Ángela Gutiérrez (ORCID: https://orcid.org/0000-0003-0217-5122)
- José Ramón Arribas (ORCID: https://orcid.org/0000-0002-7410-9450)
- Arkaitz Imaz (ORCID: https://orcid.org/0000-0001-8411-1952)
- Rafaël Delgado (ORCID: https://orcid.org/0000-0002-6912-4736)
- Esperanza Cañas‐Ruano (ORCID: https://orcid.org/0000-0002-4651-7545)
- Alexy Inciarte (ORCID: https://orcid.org/0000-0003-1896-3457)
- Luz Martı́n-Carbonero (ORCID: https://orcid.org/0000-0001-8102-4079)
- María Lagarde (ORCID: https://orcid.org/0000-0002-7712-6977)
- Pedro Gil Divasson
- José Luís Blanco (ORCID: https://orcid.org/0000-0003-2010-2744)
- Cristina Hernández Gutiérrez
Institutions
- Universidad Complutense de Madrid (ES)
- Hospital Universitario La Paz (ES)
- Bellvitge University Hospital (ES)
- University Hospital Complex Of Vigo (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Hospital Universitario 12 De Octubre (ES)
- Ajuntament de L’Hospitalet (ES)
- Hospital Universitario Príncipe de Asturias (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Fundación Seimc-Gesida (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Del Mar (ES)
- Universidad Autónoma de Madrid (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1093/cid/ciaf100
- Citations
- 4
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.58