Features of the course of perinatal period in children with bronchial asthma. Analysis of comorbid pathology

The formation and course of bronchial asthma are associated with risk factors of the perinatal period. When analyzing the morbidity of the examined patients, it was noted that almost all children had concomitant pathology represented by acute respiratory viral infections (ARVİ), diseases of ENT organs, iron-deficiency anemia, diseases of the endocrine, kidney and urinary systems, infectious and parasitic diseases, as well as concomitant allergopathology. The aim of the study is to study the peculiarities of the course of perinatal period in children with bronchial asthma and to analyze the comorbid pathology in these children. Material and methods. To solve the set tasks, 983 children with several episodes of bronchial obstruction in the anamnesis, who were subsequently diagnosed with bronchial asthma of varying severity, were included in the study. There were also 116 children under observation with a diagnosis of acute bronchitis with bronchial obstructive syndrome. These children formed the comparison group. The analysis of variance F-Fisher and nonparametric Wilcoxon U-criterion and Kruskel-Wallis criterion were used for comparison and probabilistic evaluation of differences between the values of the compared groups. Results. We took into account the following criteria: the course of pregnancy in mothers of the examined children, the obstetric and gynecological history of mothers. When analyzing concomitant pathology, it was found that infectious and helminthic-parasitic diseases were most frequently observed in children with bronchial asthma - in 516 (52.5±1.6%) cases. Conclusion. The results of the study showed that various perinatal pathologies are more often diagnosed in mothers of children with both moderate bronchial asthma and concomitant allergic rhinitis, in children with severe asthma and do not occur in the group of children with mild persistent disease. In general, concomitant diseases were significantly more common in children with severe bronchial asthma compared to mild and moderate (p<0.05).