Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants
Oral dosing with paltusotine is associated with efficient absorption from the gastrointestinal tract. Most of the administered dose is excreted unchanged. Pharmacokinetic properties of paltusotine are supportive of once-daily dosing.
Authors
- Christine Ferrara-Cook
- Alan Krasner (ORCID: https://orcid.org/0009-0005-5658-3246)
- Deepak Dalvie (ORCID: https://orcid.org/0000-0001-6196-5314)
- Lance Goulet
- Rosa Luo
- R. Scott Struthers
- Ajay Madan (ORCID: https://orcid.org/0000-0002-8563-2546)
Institutions
- Crinetics Pharmaceuticals (United States) (US)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1002/bcp.70020
- Citations
- 2
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.59