Radiation Dose–Volume Effects on Negative Tumor-Draining Lymph Nodes Affected T-cell Activation and Prognosis in Esophageal Cancer with Chemoradiotherapy
A higher radiation dose-volume parameter of TDLNs in patients with esophageal cancer undergoing CRT was significantly associated with suppression of T-cell activation and a worse prognosis. Limiting the percentage of TDLN V15 may be beneficial for improving the prognosis of CRT with or without PD-1 inhibitors.
Authors
- Zhengfei Zhu (ORCID: https://orcid.org/0000-0001-7537-3619)
- Yuwei Zheng
- Chaoyang Wu (ORCID: https://orcid.org/0000-0003-2883-9759)
- J Wang (ORCID: https://orcid.org/0009-0006-5938-168X)
- Dashan Ai (ORCID: https://orcid.org/0000-0002-2599-8861)
- Jianzhong Cao (ORCID: https://orcid.org/0000-0001-9652-4500)
- Yu-Wei Li (ORCID: https://orcid.org/0009-0005-6758-8173)
- Kuaile Zhao (ORCID: https://orcid.org/0000-0001-8663-2874)
- Min Fan (ORCID: https://orcid.org/0000-0002-2639-2415)
- Xu Yang (ORCID: https://orcid.org/0000-0001-5639-6073)
- Hui Luo (ORCID: https://orcid.org/0000-0002-1148-3429)
- Qi Liu (ORCID: https://orcid.org/0000-0002-8770-5470)
- Qin Lin (ORCID: https://orcid.org/0000-0002-4391-8706)
- Fangfang Li (ORCID: https://orcid.org/0000-0001-5298-5989)
- Yun Chen (ORCID: https://orcid.org/0000-0001-9831-0215)
- Qingsong Fan
- Jiancheng Li (ORCID: https://orcid.org/0000-0003-2148-9872)
- Jialiang Zhou
- Shihong Wei (ORCID: https://orcid.org/0000-0002-8621-8419)
- Weixin Zhao
- Jinjun Ye (ORCID: https://orcid.org/0000-0001-5234-4882)
- Zezhou Wang (ORCID: https://orcid.org/0000-0002-8051-9595)
- Jiaying Deng (ORCID: https://orcid.org/0000-0002-1744-1203)
- Hongcheng Zhu (ORCID: https://orcid.org/0000-0001-7444-5123)
- Bo Ping
- Ling Li (ORCID: https://orcid.org/0009-0000-5493-4966)
- Shuang-Li Hao
- Lu Yu (ORCID: https://orcid.org/0009-0007-8390-7343)
- Ihsuan Tseng
- Huarong Tang (ORCID: https://orcid.org/0000-0002-1034-3010)
- Xiangpeng Zheng (ORCID: https://orcid.org/0000-0001-9953-2143)
- Guang Shun Huang
Institutions
- Jiangnan University (CN)
- Jiangsu University (CN)
- Fujian Medical University (CN)
- Shanghai Medical College of Fudan University (CN)
- Nanchang University (CN)
- Shanghai University of Engineering Science (CN)
- Shanxi Medical University (CN)
- Second Military Medical University (CN)
- Fudan University (CN)
- Haikou City People's Hospital (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Genon Biological Products (China) (CN)
- Jiangxi Provincial Cancer Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- Huadong Hospital (CN)
- Central People's Hospital of Zhanjiang (CN)
- Shanxi Provincial Cancer Hospital (CN)
- Second Hospital of Shandong University (CN)
- Shanghai Municipal Human Resources and Social Security Bureau (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Wuxi Fourth People's Hospital (CN)
- Gansu Provincial Hospital (CN)
- Changhai Hospital (CN)
- Hainan General Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- Hainan 301 Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Zhenjiang City Fourth People's Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Fujian Provincial Cancer Hospital (CN)
- High Throughput Biology (United States) (US)
- Qujiang People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-4123
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23