Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
ACC1 is a metabolic vulnerability in MYC-driven multiple myeloma. Inhibiting ACC1 disrupts lipid homeostasis, induces ER stress, and causes oxidative damage, impairing cell survival. Targeting lipid synthesis pathways, especially in MYC-dependent subtypes, offers a promising therapeutic strategy for multiple myeloma.
Authors
- Domenico Maisano (ORCID: https://orcid.org/0000-0002-1221-9320)
- Caroline F. Ribeiro (ORCID: https://orcid.org/0000-0002-6785-6933)
- Fabio Socciarelli
- Giorgio Inghirami (ORCID: https://orcid.org/0000-0001-5566-0864)
- Silvia Rodrigues (ORCID: https://orcid.org/0000-0002-7239-8324)
- Eugenio Morelli (ORCID: https://orcid.org/0000-0002-8850-0442)
- Alessandra Romano (ORCID: https://orcid.org/0000-0002-6333-4433)
- Katia Todoerti (ORCID: https://orcid.org/0000-0001-6687-6871)
- Marcello Turi (ORCID: https://orcid.org/0000-0002-8760-1794)
- Kenneth Carl Anderson (ORCID: https://orcid.org/0000-0002-6418-0886)
- Mehmet Samur (ORCID: https://orcid.org/0000-0002-9978-5682)
- Nikhil C. Munshi (ORCID: https://orcid.org/0000-0002-7344-9795)
- Mariateresa Fulciniti (ORCID: https://orcid.org/0000-0002-1432-9742)
- Johany Peñailillo (ORCID: https://orcid.org/0000-0002-6781-1823)
- Anıl Aktaş Samur (ORCID: https://orcid.org/0000-0002-0183-0562)
- Na Liu
- Cesarina Giallongo (ORCID: https://orcid.org/0000-0002-7667-6088)
- Massimo F. Loda (ORCID: https://orcid.org/0000-0001-9674-8379)
- Vanessa Favasuli (ORCID: https://orcid.org/0000-0001-6466-7961)
- Annamaria Gullà (ORCID: https://orcid.org/0000-0003-4569-0095)
- Francesca Barello (ORCID: https://orcid.org/0009-0001-9295-4084)
- Nicola Amodio (ORCID: https://orcid.org/0000-0002-1345-4410)
- Claire Gao
- Yao Yao (ORCID: https://orcid.org/0000-0002-2905-6425)
- Chandraditya Chakraborty
Institutions
- Brigham and Women's Hospital (US)
- Xuzhou Medical College (CN)
- Cornell University (US)
- VA Boston Healthcare System (US)
- Magna Graecia University (IT)
- University of Catania (IT)
- Dana-Farber Cancer Institute (US)
- Dana-Farber/Harvard Cancer Center (US)
- Lincoln College (US)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2000
- Citations
- 9
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 7.25