CLINICAL AND MORPHOLOGICAL STUDY OF HEMANGIOSARCOMA IN CANINES (HSC)

Canine hemangiosarcoma (HSC) is a malignant neoplasm of mesenchymal origin that presents as a multicentric disease.The aim of this study was to review the anatomopathological and immunohistochemical findings and clinical results in canine patients who were referred for necropsy and had a histopathological diagnosis of hemangiosarcoma in the veterinary pathology laboratory of the Universidad de La Salle-Bogot.We reviewed 794 necropsy histories in the period 2010 to 2019; 17 histories were selected; clinical histories of cases that were attended at the small animal clinic of La Salle University were searched.Ki67, c-kit and SOX2 immunomarkers were used.HSC corresponded to 2.1% of mortality; 82% were males; 65% of the cases occurred in canines over 25 kg; the most affected breed was the Golden retriever (29%); the mean age of presentation was 11 years.Fifty-three percent of the patients were euthanized; 76% presented with CAH of visceral origin; the most affected organ was the lung.The most frequent clinical signs were normocytic normochromic anemia, thrombocytopenia and neutrophilic leukocytosis.Fifty-nine percent of patients were stage III, 35% were grade II and 71% were cavernous.Immunohistochemical labeling was moderate with Ki67 and mild with c-kit and SOX2 in 30%, 60% and 50% of cases, respectively.No patient received chemotherapy treatment.Further research is needed in early diagnosis, metastasis and the search for new therapeutic targets